Authors:	H. Zhao, N. Teigell Beneitez, H.S. Jena, A.G. Skirtach, P. Van Der Voort, R. Baets
Title:	Sensing of ceftazidime antibiotics in human plasma through waveguide-enhanced Raman spectroscopy assisted by a mesoporous layer
Format:	International Journal
Publication date:	7/2025
Journal/Conference/Book:	Applied Physics Letters - Photonics
Volume(Issue):	10(7) p.071302
DOI:	10.1063/5.0278252
Citations:	Look up on Google Scholar
Download:	(5.5MB)

Abstract

We report, to the best of our knowledge, the first Raman sensor for antibiotics spiked in human plasma using silicon nitride waveguides functionalized with a mesoporous silica top-cladding. Leveraging waveguiding signal enhancement, chemical enrichment, and molecular sieving, we demonstrate detection of 1 mg/l ceftazidime in plasma within 2 min. Ceftazidime quantification is achieved in plasma over 0, 20, 40, and 60 mg/l, demonstrating its potential for clinical use. Requiring minimal sample preparation, this method has great potential for point-of-need monitoring for optimal antibiotic therapy.