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Authors: K. De Vos, I. Bartolozzi, P. Bienstman, R. Baets, E. Schacht
Title: Optical Biosensor based on Silicon-on-Insulator Microring Resonators for Specific Protein Binding Detection
Format: International Conference Proceedings
Publication date: 12/2006
Journal/Conference/Book: LEOS Benelux Annual Symposium
Location: Eindhoven, Netherlands
Internal Reference: [N-555]
Download: Download this Publication (1.3MB) (1.3MB)

Abstract

We propose an integrated Silicon-on-Insulator biosensor, fabricated with Deep UV-lithography, based on resonant microring cavities in order to detect biomolecular interaction. The shift of resonance wavelength that occurs when the surroundings of a cavity is changed, can be used for sensing. An SOI microring resonator with a radius of 5 micron is capable of detecting bulk refractive index changes of 10-4. We use the avidin/biotin high affinity couple to demonstrate good repeatability and the detection of avidin concentrations down to 50 ng/ml. Further miniaturization allows for detection of extremely low analyte concentrations while lining up the microrings in arrays allows for multiparameter analyses.

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